Farmacocinética y farmacodinamia
Estudios de absorción, distribución, metabolismo y excreción de fármacos veterinarios. Modelamiento farmacocinético para optimizar dosificaciones y reducir residuos en alimentos.
Investigación aplicada
Generamos conocimiento para fortalecer la farmacología veterinaria
FARMAVET lidera líneas de investigación en farmacocinética, inocuidad alimentaria, resistencia antimicrobiana y desarrollo de metodologías analíticas. Nuestro trabajo se materializa en proyectos nacionales e internacionales, publicaciones indexadas y transferencia tecnológica.
Áreas clave
Líneas de investigación
Inocuidad alimentaria
Desarrollo de metodologías innovadoras para control de residuos, evaluación de riesgos y generación de evidencia para las políticas públicas.
Resistencia antimicrobiana
Monitoreo de RAM en producción animal, programas de stewardship y alternativas terapéuticas emergentes.
Metodologías analíticas
Validación, ampliación de alcance y acreditación de métodos multirresiduo mediante LC-MS/MS y tecnologías emergentes.
Matrices alternativas
Investigación de residuos en plumas, deyecciones, agua y bioindicadores ambientales para vigilancia integral.
Proyectos destacados
Investigación aplicada en farmacología veterinaria, inocuidad alimentaria y resistencia antimicrobiana, financiada por FONDECYT, FONDEF y organismos internacionales.
FONDECYT
En Curso
Proyecto
detalles
Investigadores:
investigadores
Resultados y logros
Resultados y logros
Publicaciones científicas
Selección de artículos recientes publicados en revistas indexadas. Revisa nuestro repositorio institucional para conocer el catálogo completo.
Artículo
Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of Risk
María Belén Vargas, Ignacia Soto, Francisco Mena, Paula Cortés, Ekaterina Pokrant, Lina Trincado, Matías Maturana, Andrés Flores, Aldo Maddaleno, Lisette Lapierre, Javiera Cornejo
Tylosin, a veterinary antimicrobial belonging to the macrolide family, is commonly used in the poultry industry. Residues generated from its use can be present in the litter and droppings of treated birds. Due to the diverse uses of poultry byproducts, such as fertilizing agricultural soils or incorporation into the diets of other animal species, there is a risk to public health, as the presence of antimicrobial residues favors the development of antimicrobial resistance, which is a global problem. Objective: This study aimed to evaluate the dissemination of tylosin residues from the litter and droppings of treated birds and untreated birds in a controlled broiler environment. Methods: Bird droppings and litter samples were collected and analyzed using HPLC-MS/MS to detect and quantify tylosin residues. Results: The residue concentrations detected in the dropping matrix only exceeded the Limits of Quantification (LOQ = 4 µg kg−1) in the treated group. The litter matrix had statistically significant differences between the study groups. The persistence of tylosin residues in the litter of birds at day 42 was 290.16 µg kg−1 in the treated group (A) and 9.35 µg kg−1 in the adjacent untreated group (B.1). Conclusions: The results indicate that exposure distance influences tylosin residue dissemination.
Artículo
Antimicrobial Residues in Poultry Litter: Assessing the Association of Antimicrobial Persistence with Resistant Escherichia coli Strains
Paula Cortés; Ekaterina Pokrant; Karina Yévenes; Aldo Maddaleno; Andrés Flores; María Belén Vargas; Lina Trincado; Matías Maturana; Lisette Lapierre; Javiera Cornejo
We set out to evaluate the persistence of sulfachloropyridazine, oxytetracycline, and enrofloxacin in broiler chicken litter following therapeutic oral treatment and its association with the isolation of Escherichia coli resistant to these antimicrobials. Methods: Forty broiler chickens were raised under controlled conditions and divided into three experimental groups, each treated with a different antimicrobial, in addition to an untreated/control group. Litter samples were collected post treatment, analyzed by UPLC-MS/MS, and processed for the isolation of E. coli. The antimicrobial susceptibility of E. coli was assessed using the Kirby–Bauer disk diffusion method. Results: Chemical analysis detected concentrations of antimicrobials throughout post treatment, reaching maxima of 42,910.14 μg kg−1, 92,712 μg kg−1, and 9567 μg kg−1 for sulfachloropyridazine, oxytetracycline plus 4-epi-oxytetracycline, and enrofloxacin plus ciprofloxacin, respectively. It was estimated that the concentrations of sulfachloropyridazine, oxytetracycline, and enrofloxacin would persist in broiler litter for 61, 244, and 514 days, respectively. A very strong association was observed between the presence of antimicrobial residues and the antimicrobial resistance of E. coli (p-value < 0.0001, and Cramer’s coefficient of 0.47), and an independence between the level of residue concentration and susceptibility (p-value 0.5262). Conclusions: The persistence of antimicrobial residues contributes to the selection of resistant bacteria, regardless of persistent antimicrobial concentrations. These findings highlight the need for stricter regulations on poultry litter management, including residue thresholds and resistance monitoring, to minimize environmental and public health risks. Proper treatment of poultry litter is essential to ensure its sustainable and safe re-use in agricultural systems.
Equipo de investigación
Nuestro capital humano combina investigadores principales, estudiantes de postgrado y colaboradores nacionales e internacionales.
Investigadores principales
Estudiantes de postgrado
Doctorado en Ciencias Silvoagropecuarias y Veterinarias, Magíster en Ciencias Veterinarias y Pecuarias, proyectos de titulación en medicina veterinaria.
Colaboraciones
LIA, CRIA, Laboratorio de Genómica Acuícola, universidades internacionales (Noruega, Canadá, España) y centros OMSA.